Blar i forfatter "Tümmler, Conny"

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    • Agnoprotein of polyomavirus BK interacts With proliferating cell nuclear antigen and inhibits DNA replication 

      Gerits, Nancy; Johannessen, Mona; Tümmler, Conny; Walquist, Mari; Kostenko, Sergiy; Snapkov, Igor; van Loon, Barbara; Ferrari, Elena; Hübscher, Ulrich; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-01)
      Background: The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein. Though mutants lacking agnoprotein are severely reduced in producing infectious virions, the exact function of this peptide remains incompletely understood. To elucidate the function of agnoprotein, we searched for novel cellular interaction partners. <p>Methods: Yeast-two hybrid assay was performed ...

    • Human endogenous retrovirus W Activity in cartilage of osteoarthritis patients 

      Bendiksen, Signy; Martinez, Inigo Zubiavrre; Tümmler, Conny; Knutsen, Gunnar; Elvenes, Jan; Olsen, Elisabeth; Olsen, Randi; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo 

      Tümmler, Conny; Snapkov, Igor; Wickström, Malin; Moens, Ugo; Ljungblad, Linda; Elfman, Maria; Winberg, Jan-Olof; Kogner, Per; Johnsen, John Inge; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-27)
      Pro-inflammatory cells, cytokines, and chemokines are essential in promoting a tumor supporting microenvironment. Chemerin is a chemotactic protein and a natural ligand for the receptors CMKLR1, GPR1, and CCRL2. The chemerin/CMKLR1 axis is involved in immunity and inflammation, and it has also been implicated in obesity and cancer.<p> In neuroblastoma, a childhood tumor of the peripheral nervous ...

    • Novel Inflammatory Mediators in Neuroblastoma Tumorigenesis 

      Tümmler, Conny (Doctoral thesis; Doktorgradsavhandling, 2019-09-20)
      <p>The tumor microenvironment is a dynamic, constantly evolving interplay between tumor cells, immune cells, endothelial and other stromal cells, and the extracellular matrix. Inflammation is an essential part of the immune system’s response against malignant growth but also a powerful pro-tumorigenic factor as cancer cells can hijack inflammatory mediators to support tumor growth. Neuroblastoma is ...

    • SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro 

      Tümmler, Conny; Dumitriu, Gianina; Wickström, Malin; Coopman, Peter; Valkov, Andrey Yurjevich; Kogner, Per; Johnsen, John Inge; Moens, Ugo; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-10)
      Neuroblastoma is a malignancy arising from the developing sympathetic nervous system and the most common and deadly cancer of infancy. New therapies are needed to improve the prognosis for high-risk patients and to reduce toxicity and late effects. Spleen tyrosine kinase (SYK) has previously been identified as a promising drug target in various inflammatory diseases and cancers but has so far not ...